David R. Liu: Key Publications (from > 200 total)

The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules. Gartner, Z. J. and Liu, D. R.  J. Am. Chem. Soc. 123, 6961-6963 (2001).  PDF 

DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. Gartner, Z. J.; Tse, B. N.; Grubina, R.; Doyon, J. B.; Snyder, T. M.; Liu, D. R. Science 305, 1601-1605 (2004). PDF  

Reaction Discovery Enabled by DNA-Templated Synthesis and In Vitro Selection. Kanan, M. W.; Rozenman, M. M.; Sakurai, K.; Snyder, T. M., Liu, D. R. Nature 431, 545-549 (2004). PDF  

Supercharging Proteins Can Impart Extraordinary Resilience. Lawrence, M. S.; Phillips, K. J.; Liu, D. R. J. Am. Chem. Soc. 129, 10110-10112 (2007). PDF  

A System for the Continuous Directed Evolution of Biomolecules. Esvelt, K. M.; Carlson, J. C.; Liu, D. R. Nature 472, 499–503 (2011). PDF  

Experimental Interrogation of the Path Dependence and Stochasticity of Protein Evolution Using Phage-Assisted Continuous Evolution. Dickinson, B. C.; Leconte, A. M.; Allen, B.; Esvelt, K. M.; Liu, D. R. Proc. Natl. Acad. Sci. USA 110, 9007-9012 (2013). PDF  

Anti-Diabetic Activity of Insulin-Degrading Enzyme Inhibitors Mediated by Multiple Hormones. Maianti, J. P.; McFedries, A.; Foda, Z. H.; Kleiner, R. E.; Du, X.-Q.; Leissring, M. A.; Tang, W.-J.; Charron, M. J.; Seeliger, M. A.; Saghatelian, A.; Liu, D. R. Nature 511, 94-98 (2014). PDF  

Cationic Lipid-Mediated Delivery of Proteins Enables Efficient Protein-Based Genome Editing In Vitro and In Vivo. Zuris, J. A.; Thompson, D. B.; Shu, Y.; Guilinger, J. P.; Bessen, J. L.; Hu, J. H.; Maeder, M. L.; Joung, J. K.; Chen, Z.-Y.; Liu, D. R. Nat. Biotechnol. 33, 73-80 (2015). PDF  

Continuous Evolution of B. thuringiensis Toxins Overcomes Insect Resistance. Badran, A. H.; Guzov, V. M.; Huai, Q.; Kemp, M. M.; Vishwanath, P.; Kain, W.; Evdokimov, A.; Moshiri, F.; Turner, K. H.; Wang, P.; Malvar, T.; Liu, D. R. Nature 533, 58-63 (2016). PDF  

Programmable Editing of a Target Base in Genomic DNA Without Double-Stranded DNA Cleavage. Komor, A. C.; Kim, Y. B.; Packer, M. S.; Zuris, J. A.; Liu, D. R. Nature 533, 420-424 (2016). PDF  

Programmable Base Editing of A•T to G•C in Genomic DNA Without DNA Cleavage. Gaudelli, N. M.; Komor, A. C.; Rees, H. A.; Packer, M. S.; Badran, A. H.; Bryson, D. I.; Liu, D. R. Nature 551, 464-471 (2017). PDF  

Treatment of Autosomal Dominant Hearing Loss by In Vivo Delivery of Genome Editing Agents. Gao, X.; Lamas, V.; Huang, M.; Yeh, W.-H.; Pan, B.; Hu, Y.-J.; Hu, J. H.; Thompson, D. B.; Shu, Y.; Li, Y.; Wang, H.; Yang, S.; Xu, Q.; Polley, D. B.; Liberman, M. C.; Kong, W.-J.; Holt, J. R.; Chen, Z.-Y.; Liu, D. R. Nature 553, 217-221 (2018). PDF 

Rewritable multi-event analog recording in bacterial and mammalian cells. Tang, W; Liu, D.R. Science 360, eaap8992 (2018). PDF 

Evolved Cas9 Variants with Broad PAM Compatibility and High DNA Specificity. Hu, J. H.; Miller, S. M.; Geurts, M. H.; Tang, W.; Chen, L.; Sun, N.; Zeina, C.; Gao, X.; Rees. H. A.; Lin, Z.; Liu, D. R. Nature 556, 57-63 (2018). PDF  

Search-and-replace genome editing without double-strand breaks or donor DNA.  Anzalone, A.V.; Randolph, P.B.; Davis, J.R.; Sousa, A.A.; Koblan, L.W.; Levy, J.M.; Chen, P.J.; Wilson, C.; Newby, G.A.; Raguram, A.; Liu, D.R. Nature,  576149157 (2019). PDF SI

An interbacterial cytidine deaminase toxin enables mitochondrial base editing. Mok, B. Y; de Moraes, M. H; Zeng, J; Bosch, D. E; Kotrys, A. V; Raguram, A.; Hsu, F; Radey, M.C; Broko Peterson, B; Mootha, V.K; Mougous, J.D;  Liu, D. R. Nature. 583, 631-637 (2020). PDF SI

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning Arbab, M.; Shen, M. W.; Mok, B.; Wilson, C.; Matuszek, Z.; Cassa, C. A.; Liu, D. R. Cell. 182, 463-480 (2020). PDF SI

In Vivo Adenine Base Editing Corrects Hutchinson-Gilford Progeria Syndrome. Koblan L. W.; Erdos, M. R.; Wilson, C.; Cabral, W. A.; Levy, J. M.; Xiong, Z.-M.; Taarez, U. L.; Davison, L.; Gete, Y. G.; Mao, X.; Newby, G. A.; Doherty, S. P.; Lin, C. Y.; Gordon, L. B.; Cao, K.; Collins, F. S.; Brown, J. D.; Liu, D. R. Nature 589, 608-614 (2021). PDF SI  “Base Editing in Progeria” NEJM Companion Paper

Phage-Assisted Evolution of Selective Botulinum Neurotoxin Proteases with Reprogrammed Substrate Specificity. Blum, T. R.; Liu, H.; Packer, M. S.; Xiong, X.; Lee, P.-G.; Zhang, S.; Richter, M.; Dong, M.; Liu, D. R. Science 371, 803-810 (2021) PDF  SI  Insights:Perspectives

Base Editing of Hematopoietic Stem Cells Rescues Sickle Cell Disease in Mice. Newby, G. A.; Yen. J. S.; Woodard, K. J.; Mayuranathan, T.; Lazzarotto, C. R.; Li, Y.; Sheppand-Tillman, H.; Porter, S. N.; Yao, Y.; Mayberry, K.; Everette, K. A.; Jang, Y.; Podracky, C. J.; Thaman, E.; Lechauve, C.; Sharma, A; Henderson, J. M.; Richter, M. F.; Zhao, K. T.; Miller, S. M.; Wang, T.; Koblan, L. W.; McCaffrey, A. P.; Tisdale, J. F.; Kalfa, T. A.; Pruett-Miller, S. M.; Tsai, S. Q.; Weiss, M. J.; Liu, D. R. Nature in press, online (2021).  PDF SI